Are you able to work at all?
To collect Unemployment Insurance (UI) benefits, you must be able to do at least some gainful employment. If you cannot work at all or can only work part-time, those circumstances will normally disqualify you from such benefits
If you are simply in a situation where you cannot do a job lifitng 50 pounds on a routine basis, but can do work with no lifting over 20 pounds, for example, you probably won't be disqualified for Unemployment Insurance benefits.
Some of these determininations are rather state specific. It never hurts to apply. The worse that can happen is the UI folks say "no".
In most states, you can file online.